the association of endothelial nitric oxide synthase gene polymorphisms and preeclampsia susceptibility
نویسندگان
چکیده
منابع مشابه
Polymorphisms of the endothelial nitric oxide synthase (NOS3) gene in preeclampsia: a candidate-gene association study
BACKGROUND The endothelial nitric oxide synthase gene (NOS3) has been proposed as a candidate gene for preeclampsia. However, studies so far have produced conflicting results. This study examines the specific role of variants and haplotypes of the NOS3 gene in a population of Caucasian origin. METHODS We examined the association of three common variants of the NOS3 gene (4b/a, T-786C and G894...
متن کاملendothelial nitric oxide synthase (enos) 4a/b and g894t polymorphisms and susceptibility to preeclampsia
background: preeclampsia is a pregnancy complication with unknown etiology and its incidence is associated with genetic and environmental factors. there are inconsistent reports related to the role of endothelial nitric oxide synthase (enos) 4a/b polymorphism on the risk of preeclampsia development. the aim of the present study was to investigate the possible influence of enos 4a/b and its syne...
متن کاملAssociation of endothelial nitric oxide synthase gene G894T polymorphism with type two diabetes and diabetic nephropathy
Background: Nitric oxide (NO) produced by endothelial NO synthase (eNOS) mediates a large range of processes, and abnormality in the production of NO has been implicated in diabetic complications including diabetic nephropathy (DN). G894T polymorphism in the eNOS gene has been shown to decreased activity the NO levels of plasma. The association between eNOS Glu298Asp gene polymorphism and DN ri...
متن کاملEndothelial Nitric Oxide Synthase (eNOS) 4a/b and G894T Polymorphisms and Susceptibility to Preeclampsia
BACKGROUND Preeclampsia is a pregnancy complication with unknown etiology and its incidence is associated with genetic and environmental factors. There are inconsistent reports related to the role of endothelial nitric oxide synthase (eNOS) 4a/b polymorphism on the risk of preeclampsia development. The aim of the present study was to investigate the possible influence of eNOS 4a/b and its syner...
متن کاملComputational Prediction of the Effects of Single Nucleotide Polymorphisms of the Gene Encoding Human Endothelial Nitric Oxide Synthase
ABSTRACT Background and Objective: Genetic variations in the gene encoding endothelial nitric oxide synthase (eNOS) enzyme affect the susceptibility to cardiovascular disease. Identification of the way these changes affect eNOS structure and function in laboratory conditions is difficult and time-consuming. Thus, it seems essential to ...
متن کاملPolymorphisms of the endothelial nitric oxide synthase gene in preeclampsia in a Han Chinese population.
BACKGROUND/AIMS The endothelial nitric oxide synthase (eNOS) gene has been enlisted by previous research as a candidate gene of preeclampsia predisposition. This study investigates the specific roles of 3 polymorphisms of the eNOS gene in a population of Chinese origin from mainland China. METHODS We studied the association of 3 commonly studied polymorphisms of the eNOS gene, namely 4b/a, T-...
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عنوان ژورنال:
gene, cell and tissueجلد ۲، شماره ۱، صفحات ۰-۰
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